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The entorhinal cortex is one of the rst regions to exhibit
neurodegeneration in Alzheimer’s disease, and as such
identication of entorhinal cortex dysfunction may aid
detection of the disease in its earliest stages. Extensive evidence
demonstrates that the entorhinal cortex is critically implicated
in navigation underpinned by the ring of spatially modulated
neurons. This study tested the hypothesis that entorhinal-based
navigation is impaired in pre-dementia Alzheimer’s disease.
Forty-ve patients with mild cognitive impairment (26 with
CSF Alzheimer’s disease biomarker data: 12 biomarker-positive
and 14 biomarker-negative) and 41 healthy control participants
undertook an immersive virtual reality path integration test, as
a measure of entorhinal-based navigation.

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